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Thursday, June 25, 2009

Alcohol Intake, Alcohol Dehydrogenase Genotypes, and Liver Damage and Disease in the Danish General Population
Am J Gastroenterol advance online publication 23 June 2009
ADH1B and ADH1C genotypes were not associated with and did not modify the effect of alcohol on biochemical tests or risk of liver disease.
Increasing alcohol intake from none to low (1–6 drinks per week) through to moderate (7–20 drinks per week) and excessive intake (21 drinks per week) leads to stepwise increases in signs of liver damage with no threshold effect, and to an increased risk of liver disease. The minor changes in biochemical tests for low alcohol intake may not account for subclinical liver disease.
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